Neovascular Age-Related Macular Degeneration Risk Based on CFH, LOC387715/HTRA1, and Smoking

Neovascular Age-Related Macular Degeneration Risk Based on CFH, LOC387715/HTRA1, and Smoking

BACKGROUND Age-related macular degeneration (AMD) is the major cause of blindness in the elderly. Those with the neovascular end-stage of disease have irreversible loss of central vision. AMD is a complex disorder in which genetic and environmental factors play a role. Polymorphisms in the complement factor H (CFH) gene, LOC387715, and the HTRA1 promoter are strongly associated with AMD. Smokin...

Cigarette smoking, CFH, APOE, ELOVL4, and risk of neovascular age-related macular degeneration.

OBJECTIVE To examine if the genes encoding complement factor H (CFH), apolipoprotein E (APOE), and elongation of very-long-chain fatty acids-like 4 (ELOVL4) confer risk of neovascular age-related macular degeneration (AMD) in an independent or interactive manner when controlling for smoking exposure. METHODS We studied 103 unrelated patients with neovascular AMD who each had at least 1 siblin...

Neovascular Age - Related Macular Degeneration

Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration

PURPOSE To examine if the gene encoding C-reactive protein (CRP), a biomarker of inflammation, confers risk for neovascular age-related macular degeneration (AMD) in the presence of other modifiers of inflammation, including body mass index (BMI), diabetes, smoking, and complement factor H (CFH) Y402 genotype. Additionally we examined the degree to which CRP common variation was in linkage dise...

Measurement of Choroidal Neovascular Area in Age-Related Macular Degeneration using Modified Otsu’s Thresholding Method

Introduction: Age-related Macular Degeneration (AMD) is one of the most important causes of irreversible  blindness in the developed world and  prevents the affected  person from  performing simple tasks such  as  reading,  driving  and  facial  recognition.  In  the  AMD,  new  blood  vessels  grow  underneath  the  retina  in  a  process  called  choroidal  neovascularisation  (CNV).  There  ...